a comparative evaluation of remineralizing ability of bioactive glass and amorphous calcium phosphate: casein phosphopeptide on early enamel lesion

background: this study was done to evaluate remineralizing potential of bioactive glasses (bags)and amorphous calcium phosphate‑casein phosphopeptide (acp‑cpp) on early enamel lesion.materials and methods: twenty freshly extracted mandibular premolars were sectioned sagittally.the buccal half was impregnated in acrylic resin blocks and treated with 37% phosphoric acid inliquid form, to demineralize enamel surface to simulate early enamel lesion. the samples were dividedinto two groups. the samples in group i were treated with acp‑cpp (gc tooth mousse) and ingroup ii with bag (sensodyne repair and protect) and stored in saliva to prevent dehydration.the samples were tested for microhardness.statistical analysis: the data obtained was analyzed using anova post hoc multiple comparisonand independent sample t‑test and presented as a mean and standard deviation.results: all the samples showed a decrease in the microhardness after demineralization.after application of remineralizing agents, group ii showed a highly significant increase in themicrohardness (p < 0.05) after 10 days, while group i showed a significant increase in microhardnessafter 15 days (p < 0.05).conclusion: both the remineralizing agents tested in this study can be considered effective inrepair and prevention of demineralization. bag showed better results initially, but eventually bothhave similar remineralizing potential. key words:casein phosphopeptide-amorphous calcium phosphate nanocomplex , novamin ,enamel,remineralization,hardness, number